The stress response is orchestrated by the release of glucocorticoids, epinephrine, and norepinephrine. This hormonal cascade forms the backbone of the body’s preparation for stress, but it also involves the suppression of other hormones related to reproduction, digestion, tissue repair, and growth.

Beyond the fight or flight reaction, the endocrine stress response includes slower-acting hormones that aid in restoring homeostasis. For instance, hormones stimulating appetite and promoting energy storage in adipose tissue play a role in counterbalancing stress effects.

From Adaptive to Harmful: Chronic Stress and Disease

While the stress response is adaptive in the face of occasional stressors, chronic stress can lead to detrimental health outcomes. An example is the endocrine system promoting energy storage in adipose tissue, potentially resulting in obesity when stress becomes chronic.

Hormones released during the stress response, designed to enhance cognitive functions in the short term, may have adverse effects on the brain under chronic activation. This includes the inhibition of neurogenesis, the growth of new brain cells, emphasizing the need to understand the long-term consequences of stress on brain health.

Effective psychological defenses can mitigate the impact of chronic stress. Maintaining a sense of control fosters a solution-driven attitude, while reducing catastrophizing helps in maintaining emotional composure. Psychological context and emotion regulation are actively explored in studies, highlighting the role of perception in shaping the individual’s response to stress.

In summary, the interplay of hormones and psychological factors in the endocrine stress response is intricate. Understanding both the hormonal foundations and psychological defenses provides insights into how stress affects the body and mind, offering avenues for effective stress management.


Sapolski, R.M. (2006). Stress, stress-related disease, and emotional regulation. In J.J. Gross (Ed.). Handbook of emotion regulation (pp. 625-673). New York, New York. The Guilford Press.

BONUS! Check your stress level here



Leave a Reply

Your email address will not be published. Required fields are marked *