Depersonalization (DP), characterized by a sensation of detachment from one’s body and a distorted sense of reality, has garnered significant attention due to its intriguing connection with anxiety. Numerous studies highlight a strong correlation between depersonalization and anxiety, particularly in social anxiety and panic disorder. Anxiety emerges as a key predictor of depersonalization disorder, where individuals feel unreal or disconnected.

Interestingly, while depersonalization can manifest during panic attacks, its relationship with anxiety is multifaceted. Clinical observations reveal that as depersonalization becomes more chronic and predominant, the frequency of panic attacks tends to decrease. A study delving into varying degrees of depersonalization disorder found a significant link between anxiety and mild to moderate cases, hinting that anxiety’s role might have been overemphasized. In anxiety disorder patients, depersonalization associates specifically with perceived threats of losing control, yet as it progresses into a distinct disorder, anxiety often recedes or becomes numbed.

Exploring the neurobiological underpinnings of DP, researchers speculate that disruptions in associative brain regions, converging towards the amygdala, may trigger DP. This connection suggests DP’s potential as a marker of psychiatric disorder severity. Notably, DP’s tie to anxiety disorders extends to panic disorder, agoraphobia, and social phobia, impacting symptom severity, phobic avoidance, and treatment resistance. This relationship also extends to mood disorders like depression.

Remarkably, a study focused on patients admitted to a trauma center unveils a compelling link between higher DP rates and the later development of post-traumatic stress disorder (PTSD). This discovery underscores DP’s relevance in the broader context of psychiatric conditions.

In essence, depersonalization’s intricate relationship with anxiety provides a window into the complexities of psychological experiences. Its convergence with anxiety disorders and its potential to predict conditions like PTSD showcase the significance of understanding depersonalization for improved diagnosis and treatment strategies in the realm of mental health.


Mula, M., Pini, S., & Cassano, G.B. (2007). The neurobiology and clinical significance of depersonalization in mood and anxiety disorders: A critical reappraisal. Journal of Affective Disorders 99: 91–99.

Sierra M, Medford N, Wyatt G, David AS (2012) Depersonalization disorder and anxiety: a special relationship? Psychiatry Res 197: 123–127 

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